George K. Christophides

This study shows that Plasmodium Protein Kinase 2 is essential for the ookinete to oocyst transition and sporozoite development in the mosquito, affecting parasite transmission.

The paper investigates how metabolic reprogramming and gut microbiota ecology in Anopheles darlingi influence Plasmodium vivax infection outcomes, identifying distinct physiological and microbial responses associated with resistance or susceptibility.

This study develops and characterizes a nanosd integral gene drive in Anopheles gambiae, achieving high gene drive rates and showing potential for malaria vector control.

This study overexpresses REL2 in Anopheles gambiae midgut and finds it causes transcriptional changes but does not induce a strong immune response against Plasmodium falciparum.

The paper develops a gene drive effector that retards Plasmodium development in transgenic Anopheles gambiae mosquitoes via midgut antimicrobial peptides, predicted to eliminate malaria across transmission scenarios.

This paper converts endogenous mosquito genes into non-autonomous gene drives for malaria control by using native regulatory sequences to express antimalarial molecules and guide-RNAs.

The paper investigates epigenetic regulation in Plasmodium berghei during its developmental transition, identifying HP1 and H3K9ac roles in gene expression and uncovering DNA motifs associated with ookinete-specific genes.

This paper evaluates Integral Gene Drive (IGD) as a more durable and flexible alternative to classical gene drives for population replacement, showing reduced resistance and prolonged transmission blockage.