Synthetic BiologyNature Biomedical EngineeringPeer-reviewed
Rewiring oncogenic signaling to RNA vector replication for the treatment of metastatic cancer
Xinzhi Zou, Elizabeth Palafox, Cynthia Zhao…·Michael Z. Lin
This paper introduces a RNA vector that replicates specifically in cancer cells with hyperactive HER2, showing lower toxicity and better efficacy against ovarian cancer in mice, and synergizes with chemotherapy.
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