Michael Z. Lin

This paper introduces SLAP2, a high-speed microscope for measuring submicron synapses and dendritic voltage in behaving mice, revealing nonlinear input-output amplification in neurons.

This paper introduces a RNA vector that replicates specifically in cancer cells with hyperactive HER2, showing lower toxicity and better efficacy against ovarian cancer in mice, and synergizes with chemotherapy.

The paper develops a genetically encoded voltage indicator to measure subthreshold voltage dynamics in neurons, revealing electrical diversity and local computation.

This study introduces a new microscopy technique to track neocortical activity with high spatial and temporal resolution, revealing fundamental dynamical elements and their properties across different neural activity regimes.

The paper identifies directional elements in brain dynamics that encode causal control hierarchies and show robustness to neural state manipulations.

This study identifies membrane curvature as a mechanism for Src kinase activation in detached cancer cells, showing that disrupting this process inhibits metastatic survival.

The paper introduces improved bioluminescent calcium sensors and opsin variants for non-invasive imaging and synaptic transmission in C. elegans.

This paper introduces squeezed light field microscopy (SLIM), a method for high-speed 3D volumetric imaging, and demonstrates its application in tracking blood cell motion and neural activity in vivo.

This paper introduces two TEMPO voltage-sensing technologies to image high-frequency neural oscillations in behaving mammals, revealing new insights into excitatory-inhibitory dynamics and wave propagation.

This paper introduces MIDAS, a method to rapidly optimize protein function in mammalian cells, demonstrating its effectiveness in improving a neurotransmitter indicator.

This study shows that cholinergic interneurons in the striatum use nicotinic receptors to limit dopamine release by depressing axonal depolarization and calcium summation.

This paper introduces miniML, a deep learning framework for automated synaptic event detection that outperforms existing methods in precision and recall across diverse preparations and species.

This paper develops a fluorogenic substrate for Chikungunya virus protease (nsP2) that improves signal-to-noise ratio and specificity for inhibitor screening.

The paper uses two-photon imaging and electrophysiological recordings to study dendritic membrane potential dynamics in mouse hippocampal pyramidal cells during behavior, revealing spatial and temporal patterns of electrical signaling.

The paper improves positively tuned voltage indicators by enhancing their kinetics and contrast for better spike detection.

This paper introduces positively tuned GEVIs that enhance spike detection in vivo with standard imaging systems, offering higher temporal resolution than calcium indicators.

The paper uses voltage imaging to show that hippocampal interneurons modulate memory-encoding pyramidal sequences through inhibition, enhancing signal-to-noise ratios during odor-cued working memory tasks.

This paper uses a novel genetically-encoded voltage indicator to study voltage dynamics in primary sensory neurons during various stimuli and injury, revealing synchronization and coding changes.

This study uses two-photon voltage imaging to record electrical activity from multiple neurons in brain slices, revealing network connectivity with single-trial resolution.

This paper demonstrates ultrafast two-photon fluorescence microscopy for in vivo neural activity imaging at high spatiotemporal resolution in awake mice.

This paper introduces an improved voltage indicator and imaging method to enable high-speed, high-resolution voltage imaging in deeply located neurons of awake mice.

The paper introduces a new set of transgenic mouse lines for precise targeting and manipulation of brain cell types, enhancing genetic tools for neuroscience research.