Author

Ikumi Oomoto

RIKEN Center for Brain ScienceORCID 0009-0004-3680-2491Unclaimed ORCID profile · follow to get notified of new preprints

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Neuroscience· 6

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cell type annotation· 3 Assay:spatial transcriptomics· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Masanori MurayamaiD· 4 shared Daiki Kiyooka· 2 shared Dan Ohtan WangiD· 2 shared Masafumi OizumiiD· 2 shared Maya OdagawaiD· 2 shared Belinda J. GoldieiD· 1 shared Chie MatsubaraiD· 1 shared Daria Merkurjev· 1 shared

Activity by Year

2018-2026 · peak 4/yr

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10 top collaborators · 15 mutual co-author links

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4 shared papersNeuroscience

Masanori MurayamaORCID

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6 papers

Recent·Most cited

Multi-area single-cell calcium imaging dataset of the mouse cortex across wakefulness, sleep, and anesthesia

Ikumi Oomoto, Daiki Kiyooka, Masafumi Oizumi, Masanori Murayama

The paper presents a dataset of single-cell calcium imaging from multiple cortical areas in mice across different physiological states.

Scientific Data · Sep 10, 2026Peer-reviewedNeuroscience

Meso2EM: a cross-scale CLEM workflow linking mesoscale functional imaging to targeted electron microscopy

Ikumi Oomoto, Motohide Murate, Jaerin Sohn, Masaru Tamura, Sayuri Harada, 直美江川, Maya Odagawa, Mitsuo Suga, Yasuo Kawaguchi, Masanori Murayama, Yoshiyuki Kubota

Meso2EM links mesoscale functional imaging to targeted electron microscopy by preserving neuron identity across scale changes using shared landmarks.

bioRxiv · Sep 1, 2026 · PreprintNeuroscience

Repetitive induction of a hibernation-like brain state slows amyloid pathology

Ikumi Oomoto, Yong Huang, Maya Odagawa, Takeshi Sakurai, Genshiro A. Sunagawa, Hiroki Sasaguri, Masanori Murayama

The paper shows that inducing a hibernation-like brain state in AD mice slows amyloid plaque accumulation and reduces neuroinflammation without targeting specific pathways.

bioRxiv · Apr 7, 2026 · PreprintNeuroscience

Single-cell resolution functional networks during unconsciousness are segregated into spatially intermixed modules

Daiki Kiyooka, Ikumi Oomoto, Jun Kitazono, Yoshihito Saito, Midori Kobayashi, Chie Matsubara, Kenta Kobayashi, Masanori Murayama, Masafumi Oizumi

The paper investigates network structure changes during sleep and anesthesia at single-cell and mesoscales, finding increased modularity at the single-cell level and spatially intermixed modules across states.

Cell Reports · Feb 1, 2026Peer-reviewedNeuroscience

m6A RNA methylation-dependent APC translation is required for local translation of beta-actin and axon development

Loïc Broix, Rohini Roy, Ikumi Oomoto, Hiroki Umeshima, Dan Ohtan Wang

The paper shows that m6A methylation regulates APC translation, which is necessary for beta-actin mRNA transport and axon development in neurons.

bioRxiv · Nov 14, 2020 · PreprintNeuroscience

Synaptic m6A Epitranscriptome Reveals Functional Partitioning of Localized Transcripts for Dynamic Tripartite Synapse Modulation

Daria Merkurjev, Wanting Hong, Kei Iida, Ikumi Oomoto, Belinda J. Goldie, Hitoshi Yamaguti, Takayuki Ohara, Shin‐ya Kawaguchi, Tomoo Hirano, Kelsey C. Martin, Matteo A. Pellegrini, Dan Ohtan Wang

The paper identifies the synaptic m6A epitranscriptome in mouse forebrain and shows its role in synaptic function and disease-related pathways.

Nature Neuroscience · Jun 27, 2018Peer-reviewedNeuroscience