Yong Huang

PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairment

This study identifies PQBP1-dependent alternative RNA splicing as a mechanism underlying HFD-induced cognitive impairment through effects on synaptic vesicle release.

Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

This study shows that nonfibrillar Aβ aggregates in APPE693Q mice disrupt presynaptic function without causing inflammation.

Repetitive induction of a hibernation-like brain state slows amyloid pathology

The paper shows that inducing a hibernation-like brain state in AD mice slows amyloid plaque accumulation and reduces neuroinflammation without targeting specific pathways.

Ubiquitination mediates protein localization in RNA virus-infected cells

The paper identifies virus-induced ubiquitination in monocytes, showing it regulates protein localization and inhibits antiviral responses.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

Identification of Novel and Differentially Expressed MicroRNAs in Goat Enzootic Nasal Adenocarcinoma

This study identifies novel and differentially expressed microRNAs in goat enzootic nasal adenocarcinoma tissues using small RNA sequencing.