Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss
Mahmoud H. Elbatreek, Zhen Li, Xiaoman Yu, Natalie Gehred, Tatiana Gromova, Jingshu Chen, Naoto Muraoka, Martin Borch Jensen, Vinay K. Kartha, Chris Carrico, Timothy Daniel Allerton, Michael E. Bowdish, Joanna Chikwe, Sanjiv Jayendra Shah, Kathleen C. Woulfe, , David J. Lefer
This study shows low-dose GLP-1RA therapy improves cardiac and hepatic function in HFpEF without weight loss, through mechanisms like reduced fibrosis and lipid accumulation.
bioRxiv · Sep 26, 2025 · PreprintPharmacology & Toxicology