Author

David J. Polhemus

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Chengchen HuiD· 1 shared Chris Carrico· 1 shared Christopher J. PetucciiD· 1 shared David A. KassiD· 1 shared David J. LeferiD· 1 shared Diego Almodiel· 1 shared Edwin YooiD· 1 shared Efthymios ZiogosiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMolecular Biology

Chengchen HuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Reduced Myocardial Serine Synthesis Impairs Functional, Metabolic, and Redox Adaptations to Cardiac Stress

Malihe Rezaee, Mohammad Keykhaei, Navid Koleini, Tegbir Panesar, Simiao Li, Nalini Salvekar, David J. Polhemus, Chengchen Hu, Mariam Meddeb, Liang Zhao, Kavita Sharma, Christopher J. Petucci, Nathaniel W. Snyder, Junichi Sadoshima, David A. Kass

This study shows that reduced myocardial serine synthesis impairs cardiac stress responses by disrupting redox balance, one-carbon metabolism, and amino acid homeostasis.

bioRxiv · Jun 2, 2026 · PreprintMolecular Biology

Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss

Mahmoud H. Elbatreek, Zhen Li, Xiaoman Yu, Natalie Gehred, Tatiana Gromova, Jingshu Chen, Naoto Muraoka, Martin Borch Jensen, Vinay K. Kartha, Chris Carrico, Timothy Daniel Allerton, Michael E. Bowdish, Joanna Chikwe, Sanjiv Jayendra Shah, Kathleen C. Woulfe, , David J. Lefer

This study shows low-dose GLP-1RA therapy improves cardiac and hepatic function in HFpEF without weight loss, through mechanisms like reduced fibrosis and lipid accumulation.

bioRxiv · Sep 26, 2025 · PreprintPharmacology & Toxicology

VERICIGUAT RESCUES cGMP PRODUCTION IN HUMAN AORTIC VASCULAR SMOOTH MUSCLE CELLS AND AUGMENTS VASORELAXATION IN AORTIC RINGS EXPOSED TO HIGH GLUCOSE

David J. Polhemus, Diego Almodiel, Tarek Harb, Efthymios Ziogos, Nuria Amat-Codina, Mark John Ranek, Lakshmi Santhanam, Gary Gerstenblith, Thorsten Martin Leucker

bioRxiv · Jun 21, 2024 · PreprintMolecular Biology