The paper shows that clonotype-restricted somatic hypermutations (SHMs) are associated with cryptic epitope recognition, while shared SHMs are permissive and not specific to particular epitopes.

bioRxiv · Oct 16, 2026 · PreprintImmunology

Universally conserved isoasparylation sustains ribosome biogenesis and function

Bruno Bonnettaz, Anna Smirnova, Marlène Vayssières, Lila Delbos, Emilie Zélie, Zaineb Fourati, Yelda Abou Khalil, Mengmeng Zhang, Wang‐Qing Liu, Michel Vidal, Johana Chicher, Lauriane Kühn, Philippe Hammann, Lola Alez-Martin, Tessa Reinert, , Alexandre Smirnov

The paper identifies isoaspartate modification of ribosomal protein uS11 as essential for ribosome biogenesis and function across all domains of life.

bioRxiv · Aug 27, 2026 · PreprintBiochemistry

Egyptian rousette bat humoral immunity to H9 influenza hemagglutinin

Anne A. Roffler, Bruno Bonnettaz, Emerson Glassey, Connor L. Murphy, Sophia Sordilla, Ceili L. Peng, Daniel P. Maurer, Eda Altan, Kristian M. Forbes, Tarja A. Sironen, Goran Bajic, Aaron G. Schmidt

The paper develops a yeast surface display library of bat antibodies to study humoral immunity to H9 influenza hemagglutinin, revealing structural and functional characteristics of bat antibodies.

bioRxiv · Jun 9, 2026 · PreprintImmunology