Author

Alexandre Smirnov

Centre National de la Recherche ScientifiqueORCID 0000-0002-9142-7979Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anna SmirnovaiD· 2 shared Johana ChicheriD· 2 shared Lauriane KühniD· 2 shared Nicolas LeulliotiD· 2 shared Philippe HammanniD· 2 shared Akinyemi M. FasemoreiD· 1 shared Alessandro Gabriele· 1 shared Alexander Gregor GeigeriD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Anna SmirnovaORCID

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Author profile →

3 papers

Recent·Most cited

A nucleolar assembly module integrates an ancestral isoaspartylase to safeguard ribosome biogenesis

Alexander Gregor Geiger, Sébastien Favre, Oscar Vadas, Tobias Von Arx, Fabian Ackle, Michael Ruoss, Liridona Zyberaj, Yash Verma, Ryan J. Separovich, Cedric A. J. Hutter, Michaela Oborská‐Oplová, Daniela Portugal-Calisto, Markus A. Seeger, Pedro Beltrão, Nicolas Leulliot, , Vikram Govind Panse

The paper identifies a nucleolar module involving Fap7 that ensures proper uS11 modification and incorporation into pre-ribosomes, safeguarding ribosome biogenesis.

bioRxiv · Sep 8, 2026 · PreprintBiochemistry

Universally conserved isoasparylation sustains ribosome biogenesis and function

Bruno Bonnettaz, Anna Smirnova, Marlène Vayssières, Lila Delbos, Emilie Zélie, Zaineb Fourati, Yelda Abou Khalil, Mengmeng Zhang, Wang‐Qing Liu, Michel Vidal, Johana Chicher, Lauriane Kühn, Philippe Hammann, Lola Alez-Martin, Tessa Reinert, , Alexandre Smirnov

The paper identifies isoaspartate modification of ribosomal protein uS11 as essential for ribosome biogenesis and function across all domains of life.

bioRxiv · Aug 27, 2026 · PreprintBiochemistry

YBEY is an essential biogenesis factor for mitochondrial ribosomes

Sabrina Summer, Anna Smirnova, Alessandro Gabriele, Ursula Toth, Akinyemi M. Fasemore, Konrad U. Förstner, Lauriane Kühn, Johana Chicher, Philippe Hammann, Goran Mitulović, Nina Entelis, Ivan Tarassov, Walter Rossmanith, Alexandre Smirnov

This study shows that human YBEY is essential for mitochondrial ribosome biogenesis, leading to respiratory deficiency and mitochondrial abnormalities.

Nucleic Acids Research · Feb 26, 2020Peer-reviewedMolecular Biology