Lauriane Kühn

Universally conserved isoasparylation sustains ribosome biogenesis and function

The paper identifies isoaspartate modification of ribosomal protein uS11 as essential for ribosome biogenesis and function across all domains of life.

Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A

This study identifies Galectin-3 as a novel ligand for GPRC5A, demonstrating its role in mediating endocytosis of the orphan GPCR in colorectal cancer cells.

CLSY docking to Pol IV requires a conserved domain critical for small RNA biogenesis and transposon silencing.

The paper identifies a conserved CYC-YPMF motif in Pol IV critical for CLSY docking, essential for small RNA biogenesis and transposon silencing.

The Chlamydomonas mitochondrial ribosome: how to build a ribosome from RNA fragments

This study characterizes the mitoribosome structure and function in Chlamydomonas reinhardtii, revealing its unique RNA assembly, protein components, and membrane attachment mechanisms.

The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis

This paper identifies URT1 as a TUTase that connects decapping activators and prevents excessive deadenylation of mRNAs, thereby avoiding siRNA biogenesis in Arabidopsis.

The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation

The paper identifies SL1, a cis-acting RNA hairpin in SARS-CoV-2 5UTR, as a key element enabling viral translation despite NSP1-mediated host translation inhibition.

Structural differences in translation initiation between pathogenic trypanosomatids and their mammalian hosts

The paper determines the structure of the 43S PIC from Trypanosoma cruzi and identifies structural differences in translation initiation compared to mammalian hosts.

Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM

The paper reports cryo-EM structures of plant mitochondrial complex I, revealing a plant-specific carbonic anhydrase domain and its role in complex stability.

Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress

The paper identifies a PSMC3 variant causing a neurosensory syndrome with deafness and cataracts due to proteotoxic stress and impaired proteasome function.

Structure of the full kinetoplastids mitoribosome and insight on its large subunit maturation

The paper presents cryo-EM structures of mature and intermediate mitoribosomes from Leishmania tarentolae and Trypanosoma cruzi, revealing the structure and maturation of the large subunit ribosomal RNA and associated maturation factors.

Structural insights into the mammalian late-stage initiation complexes

The paper presents cryo-EM structures of mammalian late-stage 48S initiation complexes with different mRNA sequences, revealing mRNA-eIF interactions and the structural role of ABCE1.

YBEY is an essential biogenesis factor for mitochondrial ribosomes

This study shows that human YBEY is essential for mitochondrial ribosome biogenesis, leading to respiratory deficiency and mitochondrial abnormalities.

RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis

This study identifies RST1 and RIPR as proteins connecting the cytosolic RNA exosome to the Ski complex in Arabidopsis, showing their role in RNA quality control.