Philippe Hammann

Universally conserved isoasparylation sustains ribosome biogenesis and function

The paper identifies isoaspartate modification of ribosomal protein uS11 as essential for ribosome biogenesis and function across all domains of life.

Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes

This study identifies how dengue virus uses mosquito Syntenin to package and secrete viral RNA into salivary exosomes, revealing a mechanism for viral RNA incorporation into extracellular vesicles.

Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A

This study identifies Galectin-3 as a novel ligand for GPRC5A, demonstrating its role in mediating endocytosis of the orphan GPCR in colorectal cancer cells.

CLSY docking to Pol IV requires a conserved domain critical for small RNA biogenesis and transposon silencing.

The paper identifies a conserved CYC-YPMF motif in Pol IV critical for CLSY docking, essential for small RNA biogenesis and transposon silencing.

The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis

This paper identifies URT1 as a TUTase that connects decapping activators and prevents excessive deadenylation of mRNAs, thereby avoiding siRNA biogenesis in Arabidopsis.

The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation

The paper identifies SL1, a cis-acting RNA hairpin in SARS-CoV-2 5UTR, as a key element enabling viral translation despite NSP1-mediated host translation inhibition.

Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress

The paper identifies a PSMC3 variant causing a neurosensory syndrome with deafness and cataracts due to proteotoxic stress and impaired proteasome function.

YBEY is an essential biogenesis factor for mitochondrial ribosomes

This study shows that human YBEY is essential for mitochondrial ribosome biogenesis, leading to respiratory deficiency and mitochondrial abnormalities.

RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis

This study identifies RST1 and RIPR as proteins connecting the cytosolic RNA exosome to the Ski complex in Arabidopsis, showing their role in RNA quality control.

Cex1 is a new component of the COPI Golgi-to-vacuole intracellular trafficking machinery

The paper identifies Cex1 as a COPI complex component involved in Golgi-to-vacuole trafficking in yeast, challenging its previously proposed role in nuclear tRNA channeling.