Drosophila melanogaster lactate dehydrogenase deficiency recapitulates the exercise intolerance of human glycogen storage disease type XI
Madhulika Rai, Shefali A. Shefali, Jason P. Tourigny, Minseo Kim, Travis G. Nemkov, Angelo D’Alessandro, Jason M. Tennessen
This study shows that loss of lactate dehydrogenase in Drosophila causes exercise intolerance and diet-dependent lethality, mirroring human LDH-A deficiency symptoms.
bioRxiv · Jul 10, 2026 · PreprintDevelopmental Biology