Travis G. Nemkov

This study shows maternal folate levels influence adult hematopoietic stem cell function through mitochondrial and chromatin changes in offspring.

This study investigates the effect of low-dose ethanol on supercooled red blood cell storage, finding it reduces hemolysis and lysophospholipid depletion while preserving energy homeostasis.

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

This study shows that loss of lactate dehydrogenase in Drosophila causes exercise intolerance and diet-dependent lethality, mirroring human LDH-A deficiency symptoms.

The paper identifies genetic regulators of the murine serum metabolome, highlighting carboxyl esterases as key controllers of fatty acid metabolism.

This study identifies shared age-associated pathway remodeling across species using comparative metabolomics, highlighting lipid and nucleotide pathways as core features of aging.

This study identifies a distinct mitochondrial metabolic phenotype in sedentary individuals using non-invasive CPET and finds reduced mitochondrial function and bioenergetics compared to active individuals.

This study shows PFOA exposure accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism, leading to increased sensitivity to environmental stress.

This study links metabolic and inflammatory changes to arterial stiffness in ultra-endurance runners using multi-omics analysis of plasma samples.

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

This study shows that long-distance trail running causes inflammation, lipid, and purine oxidation in red blood cells, indicating systemic inflammation and metabolic changes as key factors in RBC damage.

This study identifies conserved molecular responses to arsenite exposure in Drosophila, revealing shared pathways with human arsenic-related diseases.

The paper defines the Band 3 N-terminus interactome in red blood cells, revealing its role in hypoxic adaptation through BLVRB-dependent S-nitroso transfer and metabolic remodeling.

The paper investigates how G6PD variants affect red blood cell storage, transfusion performance, and recipient physiology using multiple datasets and experimental models.

This study shows Wolbachia supports Drosophila development and buffers against nutritional stress by altering metabolism and gene expression.

This study shows FAK inhibition in ovarian tumors increases macrophage CXCL13 production via omega-3 fatty acids, enhancing B cell infiltration and immunotherapy response.

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

The paper generates two novel D2hgdh loss-of-function mutations in Drosophila to study D-2HG accumulation and its effects on development and metabolism.

The paper identifies genetic factors influencing red blood cell proteome and oxidative stress in mice, highlighting hemoglobin cysteine redox status as critical for glutathione regulation.

This paper identifies Sima/Hif1 as a critical factor for establishing the larval glycolytic program in Drosophila, showing it works with dERR to regulate metabolism during development.

This study investigates how metabolic changes in endocrine-resistant ER+ breast cancer cells affect ER DNA-binding patterns and shows that DMF can restore sensitivity to endocrine therapies by targeting metabolic vulnerabilities.

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.

This study investigates how aging-related inflammation contributes to lung cancer development by analyzing gene expression data and using mouse models to assess the role of inflammation in oncogenesis.

This study shows that L2hgdh in Drosophila renal tubules prevents L-2HG accumulation, supports mitochondrial metabolism, and enables hypoxia tolerance.

The paper shows that disrupting glycolysis in Drosophila larvae leads to systemic cytokine signaling changes, nonautonomously restricting growth.

This study investigates the metabolic effects of Pyruvate kinase (Pyk) loss in Drosophila larvae, revealing disrupted glycolysis and compensatory metabolic changes.

The paper identifies Spenito's role in sex-specific metabolic differences in Drosophila fat storage cells, showing it regulates sex determination and metabolic gene expression.

This study shows CBD disrupts cholesterol homeostasis in human cell lines, altering metabolites, transcripts, and proteins related to cholesterol biosynthesis, transport, and storage.

This study investigates how specific diets can rescue metabolic defects in Spen-depleted Drosophila, showing that diet customization can alleviate metabolic dysfunction caused by genetic factors.

The paper identifies a contaminant peptide in synthetic Amyloid-β42 that inhibits cytotoxicity and fibrillation.