Shefali A. Shefali

This study shows that loss of lactate dehydrogenase in Drosophila causes exercise intolerance and diet-dependent lethality, mirroring human LDH-A deficiency symptoms.

The paper generates two novel D2hgdh loss-of-function mutations in Drosophila to study D-2HG accumulation and its effects on development and metabolism.

The paper characterizes genetic and molecular tools for studying Ldh expression in Drosophila melanogaster and finds they reveal complex tissue-specific expression patterns.

This study investigates the role of GPDH1 in Drosophila development, revealing its essential functions in oogenesis, embryogenesis, and metabolic homeostasis through genetic and metabolomics analyses.