Temporally overlapping mechanisms diversify clonal B cell responses in vivo.
Oliver P. Skinner, Saba Asad, Marcela L. Moreira, Hyun Jae Lee, Cameron G. Williams, Zheng Ruan, Jorene Lim, Ashlyn S. Kerr, Shihan Li, Chen Zhu, Wang Jin, Thiago Maass Steiner, Takahiro Asatsuma, Brooke J. Wanrooy, Zihan Liu, , Ashraful Haque
Single-cell RNA and BCR sequencing of infected mouse spleens shows class switching overlaps clonal expansion, GC-seeding clones also form plasmablasts, and SHM proceeds at constant rate.
Nature Immunology · Jun 15, 2026Peer-reviewedImmunology✦ In-depth digest