Hyun Jae Lee

Tissue-specific improvements in CD4+ T cell responses after treatment for visceral leishmaniasis.

This study examines CD4+ T cell responses in visceral leishmaniasis using single-cell RNA sequencing, revealing transcriptional heterogeneity and regulatory mechanisms affecting immune function.

Immune responses to infection modulate peripheral sympathetic neuron functions

The paper investigates how immune responses to infection affect peripheral sympathetic neuron functions, finding that cytokines and interferons alter nerve growth and neuron excitability.

Temporally overlapping mechanisms diversify clonal B cell responses in vivo.

Single-cell RNA and BCR sequencing of infected mouse spleens shows class switching overlaps clonal expansion, GC-seeding clones also form plasmablasts, and SHM proceeds at constant rate.

Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours

This study distinguishes tissue-resident memory (TRM) and exhausted T (TEX) cells in tumors by analyzing their antigen reactivity, clonality, and functional outcomes.

Deconvoluting TCR-dependent & -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay

The paper shows that AIM assays overestimate Ag-specific CD4+ T cells due to TCR-independent activation and introduces a modified assay using CXCR4-CD137+ cells for accurate characterization.

Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria

This study compares transcriptomic profiles between human malaria patients and mouse models to identify which models best reflect human disease features.

Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

This study uses dual transcriptome analysis to identify host and parasite gene expression associated with severe malaria in Gambian children, showing parasite load explains most human gene expression differences but only a third of parasite gene differences.

Estimating parasite load dynamics to reveal novel resistance mechanisms to human malaria

The paper estimates parasite load dynamics in malaria to identify host resistance mechanisms, finding novel roles for proteases and detrimental effects of interferon response.