Two retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity
Thomas W.P. Wood, William S. Henriques, Harrison B. Cullen, Mayra Romero, Cecilia Soledad Blengini, Shreya N. Sarathy, Julia Sorkin, Hilina Bekele, Chen Jin, Seungsoo Kim, Xifan Wang, Raphaëlle Laureau, Alexei Chemiakine, Rishad C. Khondker, José V.V. Isola, , Luke Edwin Berchowitz
This study shows that PNMA1 and PNMA4, derived from retrotransposons, are essential for reproductive capacity, as their absence leads to subfertility and hormonal changes in mice and associations with reproductive traits in humans.
Nature Aging · Apr 22, 2025Peer-reviewedGenetics