Cancer BiologyScientific ReportsPeer-reviewed
CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization
Donovan Drouillard, Michael Halyko, Elizabeth Cinquegrani…·Michael B. Dwinell
This study shows that CXCL12-LD, a dimeric variant of the chemokine, reduces chemotaxis in AML cells by altering receptor signaling and internalization, suggesting potential for improved CXCR4 targeting.
5 citations