Author
Medical College of WisconsinORCID 0000-0001-9890-4224Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Jungmin Lee, Karthik Srinivasan, Claudia Llinás del Torrent…·Wendell A. Lim
This study engineers orthogonal chemokine-receptor pairs to enable targeted immune cell migration and collective swarming behavior in engineered T cells.
Daniel Dorbin, Juliannie Herrera, Raven Davidson…·Thomas McFall
This paper identifies allele-specific resistance mechanisms to daraxonrasib in pancreatic cancer and demonstrates how these guide effective salvage therapies.
Roman R. Schlimgen, Shawn E. Jenjak, Alexa De La Sancha…·Brian F. Volkman
This study reveals an unconventional activation mechanism of the atypical GPCR ACKR3 using engineered nanobodies and cryo-EM, showing that extracellular pocket volume changes, not microswitch conformational shifts, drive receptor activity.
Donovan Drouillard, Michael Halyko, Elizabeth Cinquegrani…·Michael B. Dwinell
This study shows that CXCL12-LD, a dimeric variant of the chemokine, reduces chemotaxis in AML cells by altering receptor signaling and internalization, suggesting potential for improved CXCR4 targeting.
Riley R. Weaver, Anna L. Gray, Saudina Mateus-Gomes…·Douglas P. Dyer
This study shows CXCL4 enters the brain via GAG-binding to BBB proteoglycans and promotes neurogenesis through GAG-mediated oligomerization.