ImmunologyeLifePeer-reviewed
Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling
Sung Hoon Cho, Shawna K Brookens, Ariel L. Raybuck…·Mark Robin Boothby
The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.
DOI 10.7554/elife.107627.3