Synthetic auxotrophy reveals metabolic regulation of plasma cell generation, affinity maturation, and cytokine receptor signaling
Sung Hoon Cho, Shawna K Brookens, Ariel L. Raybuck, Kaylor Meyer, Yeeun Paik, Jennie A Hamilton, Jingxin Li, Karel Kalecký, Chloe Park, Juyeon Lim, Sakeenah L. Hicks, John Karijolich, Teodoro Bottiglieri, Jeffrey C. Rathmell, Denis A. Mogilenko, , Mark Robin Boothby
The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.
eLife · Oct 29, 2026Peer-reviewedImmunology