Zhuoyue Shi

This study shows that YTHDF1 mediates m6A mRNA methylation in neuronal adaptation to environmental challenges, with distinct roles in D1 and D2 neurons.

The paper identifies distinct memory storage in the direct and indirect basal ganglia pathways, showing normal motor memory is preserved in the direct pathway while aberrant inhibitory memory is stored in the indirect pathway.

This study shows that FMRP phosphorylation regulates neuronal translation via YTHDF1, revealing a mechanism for FXS pathology and suggesting YTHDF1 as a therapeutic target.