Yating Hu

The paper identifies CLCC1 as a client of Torsin ATPases, showing they organize CLCC1 to maintain ER bilayer and lipid homeostasis, with implications for MASH development.

This paper reports the first complete de novo biosynthesis of four bioactive Paris saponins in yeast by engineering sugar donor specificity and integrating biosynthetic modules.

This study identifies the enzymatic pathway for bisbenzylisoquinoline alkaloid biosynthesis and reveals a non-canonical redox-mediated mechanism for stereochemical control.

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

This study identifies and engineers a UDP-rhamnosyltransferase from Trillium tschonoskii to enable heterologous biosynthesis of polyphyllin II in yeast.

This paper uses Bayesian modeling to identify temperature-dependent enzymes in yeast metabolism, revealing squalene epoxidase as a key rate-limiting enzyme and demonstrating its role in thermotolerance.