Xiaowei Chen

The paper identifies CLCC1 as a client of Torsin ATPases, showing they organize CLCC1 to maintain ER bilayer and lipid homeostasis, with implications for MASH development.

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

This study determines the cryo-EM structure of the erlin1/2 complex and reveals its role in sequestering membrane proteins and organizing functional microdomains on the ER.

The paper shows that SAR1A and SAR1B paralogs have overlapping functions in mice, with SAR1A compensating for SAR1B deficiency.

The paper identifies EI24-RTRAF interaction as a regulator of Nox4 translation, maintaining redox balance and insulin production in pancreatic beta cells.

The paper introduces DQmB-HA, a method for sensitive quantification of carboxylic acid metabolites, enabling single-cell analysis and blood sample profiling in mice and humans.

This study introduces CARMEN, an algorithm that identifies functional noncoding variants affecting gene expression, showing improved sensitivity and lower false discovery rates compared to existing tools.

The paper introduces scCAT-seq, a method to simultaneously assay chromatin accessibility and transcriptome in single cells, and demonstrates its application in human pre-implantation embryos to reveal regulatory heterogeneity.