Molecular BiologybioRxivPreprint
HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide
Evgeny Deforzh, Prakash Kharel, Anton Karelin…·Anna M. Krichevsky
This study identifies HOXDeRNA as a long non-coding RNA that derepresses glioma-specific transcription factors by interacting with PRC2 and RNA quadruplex structures, driving astrocyte transformation into glioma-like cells.