Author

Evgeny Deforzh

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

Anna M. KrichevskyiD· 3 shared Yanhong ZhangiD· 2 shared Abdellatif El KhayariiD· 1 shared Alden John· 1 shared Amelie Kinsey· 1 shared Anton KareliniD· 1 shared Christian E. BadriD· 1 shared Erik J. UhlmanniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Anna M. KrichevskyORCID

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3 papers

Recent·Most cited

Integrated single-cell profiling of RNA and DNA interactomes reveals targetable chromatin architectures in cancer

Evgeny Deforzh, Yanhong Zhang, Hayk Mnatsakanyan, Alden John, Amelie Kinsey, Zelong Zheng, Abdellatif El Khayari, Christian E. Badr, Anna M. Krichevsky

The paper introduces SCIENCE-seq, a single-cell interactomics platform that maps RNA-RNA and DNA-DNA interactions in cancer, identifying therapeutic targets through chromatin architectures.

bioRxiv · Aug 17, 2026 · PreprintCancer Biology

HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide

Evgeny Deforzh, Prakash Kharel, Anton Karelin, Pavel V. Ivanov, Anna M. Krichevsky

This study identifies HOXDeRNA as a long non-coding RNA that derepresses glioma-specific transcription factors by interacting with PRC2 and RNA quadruplex structures, driving astrocyte transformation into glioma-like cells.

bioRxiv · Jun 30, 2023 · PreprintMolecular Biology

A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing

Rachid El Fatimy, Yanhong Zhang, Evgeny Deforzh, Mahalakshmi Ramadas, Harini Saravanan, Zhiyun Wei, Rosalia Rabinovsky, Nadiya M. Teplyuk, Erik J. Uhlmann, Anna M. Krichevsky

The paper shows miR-10b interacts with U6 snRNA, altering splicing and affecting cell viability through changes in CDC42 isoforms and levels.

Molecular Cancer · Jan 15, 2022Peer-reviewedMolecular Biology