Hiroyuki Igarashi

This study shows that vagus nerve stimulation activates the default mode network, enhancing cognitive behaviors, while vagal-independent mechanisms affect the salience network.

This study investigates stressor-specific patterns of noradrenaline release in the PVN of freely moving mice using a fluorescent sensor, revealing distinct temporal dynamics across different stressors.

This study investigates how second-scale neural dynamics in CRH neurons translate stress signals into sustained hormonal outputs, showing firing rate over seconds determines CRH release.

The paper investigates how intrinsic spike frequency adaptation (I-SFA) and inhibitory circuit dynamics contribute to extrinsic-SFA (E-SFA) in primate lateral prefrontal cortex neurons during behavior.

This study investigates how noradrenaline and corticosterone modulate CRH nerve terminal function, finding that noradrenaline inhibits Ca2+ elevations and CRH secretion, while corticosterone suppresses CRH secretion independently of Ca2+ levels.

The paper shows that repeated stress reduces intrinsic excitability of HPA axis neurons through increased cell size and membrane area, challenging conventional views on excitability plasticity.