Julio Martínez-Trujillo

This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.

This study shows that subanesthetic ketamine disrupts corollary discharge signaling in the prefrontal cortex of macaques, impairing predictive mechanisms linked to schizophrenia.

This study shows that SHANK2 variants cause hypersynchronous neuronal network activity in human iPSC-derived neurons, which is rescued by mGluR5 agonism.

This study shows that marmosets, like rodents, alternate between locomotion and pauses during navigation, with SWR rates increasing during pauses and memory-guided navigation.

The paper compares distractibility between marmosets and macaques in cognitive tasks and links it to dopamine D1 receptor expression in prefrontal parvalbumin neurons.

This study shows that hippocampal neurons use both linear and nonlinear computations to encode perceptual and memory information, challenging the traditional spatial vs. non-spatial dichotomy.

This study investigates how second-scale neural dynamics in CRH neurons translate stress signals into sustained hormonal outputs, showing firing rate over seconds determines CRH release.

This study identifies mechanisms by which neural networks overcome sensory-memory interference using input gating and tuning inversion, supported by neural data from macaques.

The paper shows that neural activity in macaque lateral prefrontal cortex better encodes attention allocation when targets and distractors are in opposite visual hemifields compared to the same hemifield.

The paper investigates how intrinsic spike frequency adaptation (I-SFA) and inhibitory circuit dynamics contribute to extrinsic-SFA (E-SFA) in primate lateral prefrontal cortex neurons during behavior.

The paper examines single neuron diversity in primate visual cortical areas V1 and LPFC, finding differences in morphology, electrophysiology, and intrinsic bursting that may underlie functional specialization.

The paper investigates whether transcriptomic profiles can predict neuronal firing-rate adaptation across brain regions and species using Patch-seq data.

This study compares spatial navigation strategies and hippocampal neural mechanisms between marmosets and rats, showing differences due to visual system adaptations.

This study examines how neural activity in the primate lateral prefrontal cortex is organized during different cognitive tasks, finding that task-related activity has a consistent spatial scaffold with task-specific reconfiguration.

This study identifies hyperexcitable network events called reverberating super bursts in MECP2 null neuronal networks and shows they can be mitigated by a calcium chelator.

The paper shows that LPFC neurons time-multiplex task features during virtual navigation, enhancing temporal encoding of spatial and non-spatial information.

This paper describes a method for improving targeting accuracy in chronic microelectrode implantations in large animals using image-guided neuronavigation and custom cranial caps.

This study examines the effects of MECP2 mutations on neuronal and network phenotypes in human stem cell-derived excitatory neurons, showing a spectrum of morphological, electrophysiological, and circuitry changes based on mutation severity.

The paper investigates how macaque lateral prefrontal cortex neurons encode working memory and perceptual representations during naturalistic vision in a virtual environment.

This study shows that neural sequences in primate prefrontal cortex encode working memory in naturalistic environments through sequential neuron activation.

The paper investigates neural coding differences between hippocampus and lateral prefrontal cortex during associative learning in primates, finding distinct spiking patterns and functional roles.

The paper investigates how feature-based attention creates non-linearities in neuronal tuning and behavior during visual motion perception by showing attentional suppressive surrounds in neurons and similar effects in human motion discrimination.

The paper identifies spontaneous traveling cortical waves in awake primates and shows they predict perceptual sensitivity and sensory processing.

This study shows that primate lateral prefrontal cortex encodes working memory representations during naturalistic behavior and that ketamine disrupts this encoding by altering neuronal firing patterns.

The paper identifies two key features of neural population responses that influence information encoding and behavioral performance.