Samuel Mestern

This study identifies recurrent inhibition as a key circuit motif regulating functional states of stress effector neurons through experimental and computational approaches.

This study investigates how second-scale neural dynamics in CRH neurons translate stress signals into sustained hormonal outputs, showing firing rate over seconds determines CRH release.

The paper investigates how intrinsic spike frequency adaptation (I-SFA) and inhibitory circuit dynamics contribute to extrinsic-SFA (E-SFA) in primate lateral prefrontal cortex neurons during behavior.

The paper examines single neuron diversity in primate visual cortical areas V1 and LPFC, finding differences in morphology, electrophysiology, and intrinsic bursting that may underlie functional specialization.

This study identifies a mechanism by which CRH neurons in the hypothalamus switch between activity states in response to stress, using electrophysiology and computational modeling.