Author

Alyssa M. Kaiser

Calico Life SciencesORCID 0009-0005-2947-8547Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

J. Graham RubyiD· 2 shared Amirali SelahiiD· 1 shared Andy J. ChangiD· 1 shared Angela Luo· 1 shared Baby Martin-McNulty· 1 shared Georgina Duenas· 1 shared Johannes RiegleriD· 1 shared John M. Patino· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

J. Graham RubyORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 14, 2026

AP-1 specifies developmental versus fibrotic extracellular matrix transcriptional programs in the lung

Alyssa M. Kaiser, Angela Luo, K. Sivasubramanian…·J. Graham Ruby

The paper identifies AP-1's role in regulating distinct ECM programs during lung development and fibrosis, showing its potential as a therapeutic target.

DOI 10.64898/2026.09.10.750752

mousescRNA-seq

𝕏 PostBluesky

Cell BiologyGeroSciencePeer-reviewedSep 20, 2025

Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells

Alyssa M. Kaiser, Amirali Selahi, Wenjun Kong, J. Graham Ruby

This study shows that substrate stiffness affects WI-38 cell proliferation and growth arrest pathways, with soft substrates inducing a unique G1 transcriptional state that is reversed by hTERT expression.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky