Konstantin A. Klötzer

The paper maps human kidney development using single-cell RNA sequencing and spatial transcriptomics, revealing fate decisions influenced by the local microenvironment.

This study identifies TET2 and INO80 as key genes in kidney disease pathogenesis through GWAS, single-cell analysis, and mouse models, showing their role in DNA damage response and disease progression.

Multi-omic and spatial profiling of 81 human kidney samples resolves four tissue microenvironments; the fibrotic one's gene signature is reported to beat histopathology at predicting outcome.