Author
Children's Hospital of PhiladelphiaORCID 0000-0002-0565-7752Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Hailong Hu, Yuhao Tan, Irina S. Shkundina, Richard Madnick, Jing Hu, Hongyi Zhang, Ziqi Yang, Tong Wang, Xuexin Yu, Julia Fleming, Mingyao Pan, Yizhou Wang, Yuanyuan Pang, Drew Weissman, Bo Li
The paper identifies the Bhlhe40-S100a4 cascade as a key regulator of cancer cell mitochondrial transfer from T cells, offering a target for immunotherapy.
bioRxiv · Oct 28, 2026 · PreprintImmunology
Mingyao Pan, Jing Hu, Yizhou Tracy Wang, Yuhao Tan, Hailong Hu, Ziqi Yang, Julia Fleming, Yuanyuan Pang, Bo Li
TCRmeta integrates antigen specificity with TCR repertoires to enable cross-individual and longitudinal immune monitoring by revealing conserved patterns and technical variation robustness.
bioRxiv · Oct 16, 2026 · PreprintBioinformatics
Yuhao Tan, Ziqi Yang, Tong Wang, Hailong Hu, Julia Fleming, Mingyao Pan, Laurence Crane Eisenlohr, Bo Li
The paper develops epiVIP, a deep learning framework to predict HLA-I peptide abundance from (sc)RNA-seq data, showing that peptide abundance and non-selfness jointly determine antigenicity and predict tumor reactivity and survival.
bioRxiv · May 10, 2026 · PreprintBioinformatics
Mingyao Pan, Yuhao Tan, Yizhou Tracy Wang, Jing Rong Hu, Julia Fleming, Hailong Hu, Ziqi Yang, Xiaowei Zhan, Bo Li
The paper introduces THNet, a method to analyze HLA-TCR cross-reactivity, revealing new disease associations and improving transplantation outcomes.
Science Advances · Oct 24, 2025Peer-reviewedBioinformatics
Xiujie Liang, Hongbo Liu, Hailong Hu, Jianfu Zhou, Amin Abedini, Andrea Navarro, Konstantin A. Klötzer, Katalin Suszták
This study identifies TET2 and INO80 as key genes in kidney disease pathogenesis through GWAS, single-cell analysis, and mouse models, showing their role in DNA damage response and disease progression.
bioRxiv · Feb 2, 2024 · PreprintGenetics