Hongbo Liu

Inherited Susceptibility to Urinary Tract Infections from Kidney Papilla to Bladder

This study identifies 36 genetic loci associated with recurrent UTIs and highlights PSCA as a key gene involved in urinary epithelial defense against bacteria.

mV2G: a multiomic atlas for tissue-specific variant-to-gene prioritization

A web atlas counts evidence from 24 types for 188,634,118 variant-gene pairs across 50 human tissues; 1,530,420 pairs pass a high-confidence cutoff, 87% of them tissue-specific.

Multiomic Integration Reveals Transposable Element-Embedded Regulatory Variants Underlying Brain Aging

The paper integrates GWAS variants with TE-derived regulatory elements to identify brain aging-associated regulatory variants and their target genes.

Fibulin-2 transduces a matrix-to-metabolism signal in kidney fibrosis

This study identifies Fibulin-2 as a matrix cue that transduces fibrotic ECM remodeling into mitochondrial metabolic reprogramming in kidney fibrosis.

Genetic Studies Highlight the Role of TET2 and INO80 in DNA Damage Response and Kidney Disease Pathogenesis

This study identifies TET2 and INO80 as key genes in kidney disease pathogenesis through GWAS, single-cell analysis, and mouse models, showing their role in DNA damage response and disease progression.

Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression

Multi-omic and spatial profiling of 81 human kidney samples resolves four tissue microenvironments; the fibrotic one's gene signature is reported to beat histopathology at predicting outcome.

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

The paper maps genetic variants to cell types in the kidney to identify disease mechanisms and drug targets.

Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets

The paper maps the regulatory landscape of the mouse kidney at single cell resolution, identifying key transcription factors and regulatory circuits, and linking variants to kidney disease.