Kaixuan Gao

This paper introduces a de novo design strategy called 'click fusion' to create stable GPCR fusion proteins, enabling structural studies via cryo-EM.

This study determines the structure of mouse BOCT1 and reveals its function as an independent iron transporter using cryo-EM and functional assays.

The paper stabilizes GPCRs in specific conformations using a fusion protein and screens nanobodies to identify conformation-specific binders.