De novo Design of A Fusion Protein Tool for GPCR Research
Kaixuan Gao, Xin Zhang, Jia Nie, Hengyu Meng, Weishe Zhang, Boxue Tian, Xiangyu Liu
This paper introduces a de novo design strategy called 'click fusion' to create stable GPCR fusion proteins, enabling structural studies via cryo-EM.
Proceedings of the National Academy of Sciences · Jul 14, 2025Peer-reviewedBiophysics