VIPerturb-seq enables genome-wide CRISPR perturbation screens using probe-based detection, improving throughput and efficiency for single-cell analysis.

bioRxiv · Aug 20, 2026 · PreprintGenomics

Glandular architecture and malignant behaviour in colorectal cancer is regulated by the sialomucin Podocalyxin.

Erin M. Cumming, Kai Rakovic, Kathryn A.F. Pennel, Laura A Galbraith, Emma Sandilands, Louise Mitchell, Lynn McGarry, René Jackstadt, Kathryn Gilroy, Colin Nixon, Owen James Sansom, John P. C. Le Quesne, Karen Blyth, Joanne Edwards, David M. Bryant

This study identifies Podocalyxin as a regulator of glandular architecture in colorectal cancer, showing its role in promoting tumour growth and metastasis.

bioRxiv · Jul 10, 2026 · PreprintCancer Biology

Population-scale sequencing resolves correlates and determinants of latent Epstein-Barr Virus infection

Sherry S. Y. Nyeo, Erin M. Cumming, Oliver S. Burren, Meghana S. Pagadala, Jacob C. Gutierrez, Thahmina A. Ali, Laura C. Kida, Yifan Chen, Fengyuan Hu, Benjamin Hollis, Margarete A. Fabre, Stewart MacArthur, Quanli Wang, Leif S. Ludwig, Kushal K. Dey, , Caleb A. Lareau

The paper uses population-scale whole genome sequencing to identify EBV DNA as a biomarker for respiratory, autoimmune, and cardiovascular diseases and identifies genetic determinants of EBV persistence.

bioRxiv · Jul 18, 2025 · PreprintGenetics