Author

Matthew S. Fischer

University of Wisconsin–MadisonORCID 0009-0005-7713-8205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Emily A. ChapmaniD· 2 shared Holden T. RogersiD· 2 shared Song JiniD· 2 shared Ying GeiD· 2 shared Andrew J Perciaccante· 1 shared Boris KricheliD· 1 shared Carmen C Sucharov· 1 shared Charlotte UetrechtiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Emily A. ChapmanORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintNov 2, 2026

An Integrated Experimental and Informatics Strategy Enables Large Proteoform Identification in Top-Down Proteomics

Matthew S Fischer, Eli J Larson, Ryan K Schroeder…·Ying Ge

The paper presents an integrated experimental and informatics strategy to improve identification of large proteoforms in top-down proteomics, achieving identification of proteoforms up to 223 kDa.

DOI 10.64898/2026.10.30.763218

humanproteomics

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BiochemistryJournal of the American Chemical SocietyPeer-reviewedAug 14, 2025

Structural Heterogeneity of Proteoform-Ligand Complexes in AMP-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry

Hsin‐Ju Chan, Boris Krichel, Liam J. Bandura…·Ying Ge

This study uses integrated top-down mass spectrometry to reveal structural heterogeneity in AMPK proteoform-ligand complexes, uncovering new insights into kinase regulation.

4 citations

proteomicsexperimental assay

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BiochemistryAnalytical ChemistryPeer-reviewedJun 20, 2025

Native Top-Down Proteomics of Endogenous Protein Complexes Enabled by Online Two-Dimensional Liquid Chromatography

Matthew S. Fischer, Holden T. Rogers, Emily A. Chapman…·Ying Ge

The paper develops a method for high-throughput structural analysis of endogenous protein complexes using native top-down proteomics.

13 citations

humanproteomics

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