Song Jin

Integrated Multi-Omics Enabled by Sequential Extraction for Comprehensive Molecular Profiling of Small Extracellular Vesicles

This paper presents a multi-omics platform for simultaneous lipid, metabolite, and protein analysis of sEVs using sequential extraction and mass spectrometry, achieving deep and reproducible characterization with 10 million sEVs.

Structural Heterogeneity of Proteoform-Ligand Complexes in AMP-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry

This study uses integrated top-down mass spectrometry to reveal structural heterogeneity in AMPK proteoform-ligand complexes, uncovering new insights into kinase regulation.

Rational design of a foldon-derived heterotrimer guided by quantitative native mass spectrometry

This study designs a stable heterotrimeric protein complex using rational design and native mass spectrometry, validated by X-ray crystallography.

Native Top-Down Proteomics of Endogenous Protein Complexes Enabled by Online Two-Dimensional Liquid Chromatography

The paper develops a method for high-throughput structural analysis of endogenous protein complexes using native top-down proteomics.