Author

Hsin‐Ju Chan

University of Wisconsin–MadisonORCID 0000-0002-4488-5053Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Holden T. RogersiD· 4 shared Ying GeiD· 4 shared Boris KricheliD· 3 shared Charlotte UetrechtiD· 2 shared David S. RobertsiD· 2 shared Emily A. ChapmaniD· 2 shared Liam J. BanduraiD· 2 shared Man‐Di WangiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersBiochemistry

Holden T. RogersORCID

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4 papers

Recent·Most cited

BiochemistryScience AdvancesPeer-reviewedSep 4, 2026

AMPK Phosphorylation Proceeds Through Hierarchical Proteoform Cascades Revealed by Integrated Mass Spectrometry

Boris Krichel, Hsin‐Ju Chan, Liam J. Bandura…·Ying Ge

The paper uses integrated mass spectrometry to show AMPK phosphorylation occurs through hierarchical proteoform cascades with specific kinetic priorities and regulatory control.

1 citation

proteomicsexperimental assay

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BiochemistryJournal of the American Chemical SocietyPeer-reviewedAug 14, 2025

Structural Heterogeneity of Proteoform-Ligand Complexes in AMP-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry

Hsin‐Ju Chan, Boris Krichel, Liam J. Bandura…·Ying Ge

This study uses integrated top-down mass spectrometry to reveal structural heterogeneity in AMPK proteoform-ligand complexes, uncovering new insights into kinase regulation.

4 citations

proteomicsexperimental assay

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BiochemistryJournal of Molecular and Cellular CardiologyPeer-reviewedApr 1, 2025

In-depth Characterization of S-Glutathionylation in Ventricular Myosin Light Chain 1 Across Species by Top-Down Proteomics

Emily A. Chapman, Holden T. Rogers, Zhan Gao…·Ying Ge

The paper identifies and quantifies S-glutathionylation in ventricular myosin light chain 1 across human, swine, and mouse cardiac tissues using top-down proteomics.

3 citations

humanmouse

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BioinformaticsBioinformaticsPeer-reviewedJun 1, 2023

MASH Native: A Unified Solution for Native Top-Down Proteomics Data Processing

Eli J. Larson, Melissa R. Pergande, Michelle E. Moss…·Ying Ge

MASH Native provides a unified software solution for processing native top-down proteomics data, offering database searching and analysis tools in a user-friendly interface.

39 citationstop 5%

proteomicsstatistical model

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