Author

Kyle Hinkle

Children's Hospital of PhiladelphiaORCID 0009-0005-7937-1246Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Aime T. FrancoiD· 2 shared Amber R. IsazaiD· 2 shared Andrew J. BaueriD· 2 shared Erin Renée ReichenbergeriD· 2 shared Julio C. Ricarte‐FilhoiD· 2 shared Nicholas E. BambachiD· 2 shared Christian Hernandez-Padilla· 1 shared Tricia R BhattiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 34 mutual co-author links

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2 shared papersCancer Biology

Aime T. FrancoORCID

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2 papers

Recent·Most cited

Cancer BiologyFrontiers in OncologyPeer-reviewedJan 7, 2026

KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer

Nicholas E. Bambach, Julio C. Ricarte‐Filho, Erin Renée Reichenberger…·Aime T. Franco

This study identifies KEAP1 mutations in thyroid cancer, showing they activate the NRF2 pathway, promote cell growth and migration, and reduce drug response.

2 citations

humanwhole-exome sequencing

𝕏 PostBluesky

Cell BiologybioRxivPreprintNov 17, 2025

Single-cell analysis reveals the cellular and transcriptional diversity of thyrocytes in the normal pediatric thyroid

Erin Renée Reichenberger, Nicholas E. Bambach, Zachary Spangler…·Aime T. Franco

The paper uses single-nuclei RNA sequencing to analyze pediatric thyroid cells, identifying seven major cell types and seven thyrocyte subclusters with distinct functions.

DOI 10.1101/2025.11.17.687863

humanbulk RNA-seq

𝕏 PostBluesky