ImmunologybioRxivPreprint
The active secretion of a subunit of IL-12 by tissue cells is regulated by Valosin-Containing Protein and intracellular calcium redistribution.
Elizabeth M. Hill, Jaclyn Bredenkamp, Gabrielle C McBroom…·Nevil J. Singh
The paper identifies VCP inhibition and calcium flux as mechanisms enabling stromal cells to secrete the IL-12 p35 subunit, regulating localized cytokine activity.
DOI 10.64898/2026.01.28.702376