Author

Emma J. Hedgepeth

Children's Hospital of PhiladelphiaORCID 0009-0005-8767-6402Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Laurence Crane EisenlohriD· 2 shared Mary E. O'Mara· 2 shared Nhu Le· 2 shared Stephen D. CarroiD· 2 shared Chaitali BhadiadraiD· 1 shared Christabel Ameyaw Baah· 1 shared Coral M. KasdeniD· 1 shared Hansell H. StedmaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Laurence Crane EisenlohrORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 2, 2026

Generation and MHC class II loading of an endogenous influenza epitope revealed by a T cell receptor-like antibody

Linlin Yang, Michael John Hogan, Stephen D. Carro…·Laurence Crane Eisenlohr

An mRNA vaccine-based pipeline generated a TCR-like antibody to study noncanonical MHC-II antigen processing of an influenza epitope.

DOI 10.64898/2026.06.25.734564

proteomicsexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintMar 11, 2025

Endogenous antigen processing promotes mRNA vaccine CD4+ T cell responses

Julia E. Rood, Suh Kyung Yoon, Mary K. Heard…·Laurence Crane Eisenlohr

This study shows that endogenous antigen processing via MHC II is critical for mRNA-LNP vaccine-induced CD4+ T cell responses, challenging the traditional view of exogenous antigen processing.

3 citations

mouseexperimental assay

𝕏 PostBluesky