Stephen D. Carro

An mRNA vaccine-based pipeline generated a TCR-like antibody to study noncanonical MHC-II antigen processing of an influenza epitope.

This study shows fractalkine-conjugated mRNA-LNP can target and modify CD8+ T cells in vivo, enabling transient expression of proteins like IL-2 and CD62L.

This paper develops an mRNA platform to generate monospecific Th1 responses in mice by encoding epitopes linked to MHCII, demonstrating efficacy against Salmonella infection.

This study shows IL-18 can induce both hyperinflammation and immunodeficiency in mice depending on the infectious trigger, leading to MAS and poor viral clearance.

This study shows that endogenous antigen processing via MHC II is critical for mRNA-LNP vaccine-induced CD4+ T cell responses, challenging the traditional view of exogenous antigen processing.