Laurence Crane Eisenlohr

Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4+ T cell responses

The paper develops an MHC-II tetramer to track TcdB-specific CD4+ T cells in mice, validating its use in identifying Tfh cells and generating toxin-specific T cells.

Generation and MHC class II loading of an endogenous influenza epitope revealed by a T cell receptor-like antibody

An mRNA vaccine-based pipeline generated a TCR-like antibody to study noncanonical MHC-II antigen processing of an influenza epitope.

AI-enabled virtual immunopeptidomics links quantitative neoantigen presentation to immunogenicity

The paper develops epiVIP, a deep learning framework to predict HLA-I peptide abundance from (sc)RNA-seq data, showing that peptide abundance and non-selfness jointly determine antigenicity and predict tumor reactivity and survival.

Role of IL10 signaling in the circadian control of host response to Influenza infection

The paper investigates how IL-10 signaling interacts with circadian rhythms to influence the host response to influenza infection, finding that blocking IL-10 signaling abolishes time-of-day-specific protection.

Cutting Edge: An mRNA Platform to Create Isolated, Monospecific Th1 Responses

This paper develops an mRNA platform to generate monospecific Th1 responses in mice by encoding epitopes linked to MHCII, demonstrating efficacy against Salmonella infection.

Multimodal induction of fulminant HLH by IL-18 includes virus-specific NK immunodeficiency

This study shows IL-18 can induce both hyperinflammation and immunodeficiency in mice depending on the infectious trigger, leading to MAS and poor viral clearance.

Endogenous antigen processing promotes mRNA vaccine CD4+ T cell responses

This study shows that endogenous antigen processing via MHC II is critical for mRNA-LNP vaccine-induced CD4+ T cell responses, challenging the traditional view of exogenous antigen processing.

Human erythroid progenitors express antigen presentation machinery

The paper identifies human erythroid progenitors as immune mediators expressing MHC class II machinery and interacting with T cells in the fetal liver.