Endogenous antigen processing promotes mRNA vaccine CD4+ T cell responses
Julia E. Rood, Suh Kyung Yoon, Mary K. Heard, Stephen D. Carro, Emma J. Hedgepeth, Mary E. O'Mara, Michael J. Hogan, Nhu Le, Hiromi Muramatsu, Kieu Lam, Petra Schreiner, Coral M. Kasden, Hansell H. Stedman, Ryan Andrew Langlois, James Heyes, , Laurence Crane Eisenlohr
This study shows that endogenous antigen processing via MHC II is critical for mRNA-LNP vaccine-induced CD4+ T cell responses, challenging the traditional view of exogenous antigen processing.
bioRxiv · Mar 11, 2025 · PreprintImmunology