Sarah Kaspar

AlphaDesign uses AlphaFold to design novel protein structures, including monomers, dimers, and higher-order complexes, showing structural integrity and conformational switching capabilities.

This paper uses time-resolved multi-omics analysis of kidney fibrosis to identify novel mechanisms and validate transcription factors involved in collagen deposition.

This study develops a protocol to induce territorial behaviors and dominance hierarchies in laboratory mice, revealing differences in hierarchy formation between strains.

The paper uses single molecule multi-omics to show DNA methylation can block transcription factor binding at cell-type-specific enhancers, but not all enhancers.