Elisabetta Cacace

The paper maps E. coli capsule serotypes using genomic data, identifies novel K-types, and develops an in silico serotyping tool applicable to diverse E. coli genomes.

AlphaDesign uses AlphaFold to design novel protein structures, including monomers, dimers, and higher-order complexes, showing structural integrity and conformational switching capabilities.

This study identifies nitroxoline's broad antibacterial activity against Gram-negative bacteria, its mode of action involving metal homeostasis and outer membrane disruption, and resistance mechanisms across multiple species.

The paper maps antibiotic cross-resistance and collateral sensitivity interactions using chemical genetic data and validates findings experimentally.