Author

Jonathan D. Proto

Sanofi (United States)ORCID 0009-0005-9950-4720Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Dimitry OfengeimiD· 2 shared Erin A. TeepleiD· 2 shared Joseph Gans· 2 shared Lilu Guo· 2 shared Mindy ZhangiD· 2 shared Sean K. RyaniD· 2 shared Timothy R. HammondiD· 2 shared Alexander Brezzani· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Dimitry OfengeimORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologyiSciencePeer-reviewedJul 31, 2025

Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy

Jeremy Y. Huang, Brian Freed, Martin Hanus…·Can Kayatekin

The paper inhibits Elovl1 in a mouse model of ALD to reduce VLCFA accumulation, finding it corrects lipid pathways but also causes unexpected transcriptional changes.

6 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 2, 2021

Microglia ferroptosis is prevalent in neurodegenerative disease and regulated by SEC24B

Sean K. Ryan, Matija Zelic, Yingnan Han…·Timothy R. Hammond

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

4 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 9, 2021

Disrupted microglial iron homeostasis in progressive multiple sclerosis

Jonathan D. Proto, Mindy Zhang, Sean K. Ryan…·Dimitry Ofengeim

This study identifies SPMS-enriched microglia subsets with disrupted iron homeostasis and oxidative stress using snRNA-seq and validates findings with histology and RNA-scope.

7 citations

humansnRNA-seq

𝕏 PostBluesky