Author

Yingnan Han

Shanghai Artificial Intelligence LaboratoryORCID 0000-0002-6356-4052Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Approach:benchmark study· 2 Research Focus:GWAS / association mapping· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Deepak K. RajpaliD· 2 shared Dinesh KumariD· 2 shared Erin A. TeepleiD· 2 shared Lilong Wang· 2 shared Mahdiar SadeghiiD· 2 shared Srinivas ShankaraiD· 2 shared Xiaosong Wang· 2 shared Zhenyu TangiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Deepak K. RajpalORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Scaling genetic discovery through automated post-GWAS interpretation

Libo Qiao, Shuang Gu, Ye Yang, Yingnan Han, Xuanzhao Li, Xing Wan, Xiwen Zhang, Qinhao Zhang, Tingting Hu, Yan Zhang, Faming Chen, Jiaheng He, Jingxuan Wang, Zhenyu Tang, Peng Ye, , Fulong Yu

This paper introduces PGI, a system that automates post-GWAS interpretation, achieving high recovery of findings and enabling cross-study biological evidence accumulation.

bioRxiv · Oct 27, 2026 · PreprintGenetics

MolClaw: An Autonomous Agent with Hierarchical Skills for Drug Molecule Evaluation, Screening, and Optimization

Lisheng Zhang, Lilong Wang, Xiangyu Sun, Wei Tang, Haoyang Su, Yuehui Qian, Qikui Yang, Qingsong Li, Zhenyu Tang, Haoran Sun, Yingnan Han, Yankai Jiang, Wenjie Lou, Bin Zhou, Xiaosong Wang, , Zhengwei Xie

MolClaw is an autonomous agent that evaluates, screens, and optimizes drug molecules using a hierarchical skill system, achieving state-of-the-art performance in complex workflows.

bioRxiv · Apr 6, 2026 · PreprintBioinformatics

Microglia ferroptosis is prevalent in neurodegenerative disease and regulated by SEC24B

Sean K. Ryan, Matija Zelic, Yingnan Han, Erin A. Teeple, Luoman Chen, Mahdiar Sadeghi, Srinivas Shankara, Lilu Guo, Cong Li, Fabrizio Pontarelli, Elizabeth H. Jensen, Dinesh Kumar, Mindy Zhang, Joseph Gans, Bailin Zhang, , Timothy R. Hammond

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

bioRxiv · Nov 2, 2021 · PreprintNeuroscience

Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson's Disease Risk

Yingnan Han, Erin A. Teeple, Srinivas Shankara, Mahdiar Sadeghi, Cheng Zhu, Dongyu Liu, FinnGen, Clarence Wang, Francesca Frau, Katherine Wood Klinger, Stephen L. Madden, Deepak K. Rajpal, S. Pablo Sardi, Dinesh Kumar

This paper computes a genome-wide polygenic risk score for Parkinson's Disease using 6.2 million variants and finds it strongly associates with increased disease risk and earlier onset.

medRxiv · Oct 16, 2020 · PreprintGenetic & Genomic Medicine