Timothy R. Hammond

This study develops anti-TfR1 NANOBODY(R) molecules that deliver siRNA and ASO payloads to muscle and CNS tissues, achieving significant mRNA knockdown.

This study identifies glial state changes and RIPK1 signaling as key features of ALS pathogenesis, showing that blocking RIPK1 delays disease onset and modulates glial responses.

The paper shows enzymatic dissociation causes gene expression changes in microglia and proposes a protocol to reduce these artifacts in scRNA-seq.

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

The paper profiles gene expression in human microglia from 141 patients, identifies population shifts in acute brain injury, maps eQTLs, and fine-maps Alzheimer's risk variants using hIPSC-derived macrophages.

This study identifies SPMS-enriched microglia subsets with disrupted iron homeostasis and oxidative stress using snRNA-seq and validates findings with histology and RNA-scope.

This study identifies nine distinct microglial states in mice across lifespan and after injury using single-cell RNA sequencing, revealing persistent and age-related changes.